Work-related Asthma Occupational asthma information, causes, and asthma relief by Lawrence Martin, M.D.

 
What is asthma?

Before discussing work-related asthma I will briefly define asthma in general. Asthma is a pulmonary condition characterized by episodic airflow obstruction that is at least partially reversible. Obstruction to flow of air occurs in the bronchial tubes within the lungs. In asthmatics these air passages become inflamed when affected by various triggers; the inflammation in turn leads to narrowing (bronchoconstriction) and resultant respiratory symptoms. Asthma symptoms typically manifest as wheezing, chest tightness, cough and shortness of breath. Wheezing is a high pitched sound generated by air going through the constricted passages. Shortness of breath is typically felt with exertion, but in severe cases can be at rest. Symptoms are highly variable, from mild and non-limiting, to disabling and, rarely, fatal. Overall, asthma is a common condition, affecting in some fashion an estimated 5-10 percent of the general population.


What is the cause of asthma?

At a basic level the cause of asthma is unknown. Given an individual's predisposition to asthma, a variety of factors can trigger symptoms (Table 1). Perhaps the most common trigger in adults is respiratory viral infections, including the common cold. Less common, but very important, are allergens, substances that when inhaled can react with the host's antibodies to generate an allergic response. Allergens include various plant pollens, animal furs, excreta from house mites, proteins in shellfish, and some metals. Allergens play a major role in many cases of occupational asthma. Irritants can also trigger an asthma attack through a non-allergic mechanism, by directly injuring cells within the lungs. Other triggers of an asthma attack include climate changes; exercise, particularly in cold weather; certain medications such as aspirin; and acid-reflux from the stomach. Although everyone is subjected to the types of triggers listed in Table 1, only the 5-10 percent of the population with asthma are prone to develop symptoms when so exposed.
Table 1

Some common triggers of symptoms (the asthma attack) in patients with asthma

    Respiratory viral infections
    Allergies (e.g., to pollen, animal fur, grain dust, dust mites, shell fish, diisocyanates, etc.)
    Irritants (smoke, fumes, gases, other pollutants)
    Climate changes
    Exercise (particularly in cold air)
    Sinus infections
    Drug reactions, e.g., aspirin
    Stomach acid reflux

What is work-related asthma?

There are two basic types of work-related asthma.

1. Occupational asthma

With latency period - allergic Without latency period - irritant (RADS)
2. Work-aggravated asthma

The first type - also called occupational asthma is when the asthma first begins on the job, and is directly related to the job. Two types of occupational asthma are distinguished by whether symptoms appear after a latency period, i.e., a period of time (weeks to years) between the very first exposure and first development of symptoms.

With latency period.

This is allergic or immunologic asthma. With repeated exposure over time to an allergen, such as latex in hospital gloves, the worker becomes sensitized to the allergen. The next exposure after sensitization might lead to symptoms diagnosed as asthma.

Without a latency period.

This is non-allergic or non-immunologic asthma, and is better known as irritant-induced asthma. It is also sometimes called reactive airways dysfunction syndrome, or RADS. The irritant - typically a chemical fume - inflames the airways and the worker has symptoms immediately.

In both types of occupational asthma symptoms can range from mild to life-threatening, and leave the worker chronically disabled. Generally, once a worker is sensitized he or she must no longer be exposed to the allergen, as even tiny amounts can trigger renewed symptoms.
The second type of work-related asthma is called work-aggravated asthma. This is when pre-existing asthma (such as childhood or teenage asthma) flares up because of exposure to some allergen or irritant on the job. Distinction between true occupational asthma and work-related asthma is often important because workers' compensation agencies may handle them differently; to the individual patient, though, asthma is asthma, and overall management should be no different.
How common is work-related asthma?

It is estimated that one out of 10 adult asthmatics have a work-related connection, i.e., asthma either caused directly by their occupation or with preexisting asthma reactivated by the job. There are approximately 200 million people in the U.S. age 18 or older (source: www.census.gov). Given a 5-10 percent prevalence rate of asthma, an estimated 1-2 million US adults have asthma in some way related to work place exposures. (These are prevalence estimates, and do not mean 1-2 million new cases each year.)

What are some allergens that can cause work-related asthma?

Many people mistakenly equate all asthma with allergy, but in fact allergy is only one of the potential triggers of an asthma reaction (Table 1), including work-related asthma. However, on the job, allergy is an important cause of asthma. Over 250 substances have been identified in the workplace that can elicit an antigen-antibody response and cause occupational asthma. These allergens are typically categorized as high or low molecular weight compounds, but the two groups cannot be distinguished on clinical grounds. Generally, high molecular weight compounds are mostly proteins from animals and plants; low molecular weight compounds include numerous chemicals. Examples of these compounds and the occupations at risk are given in Table 3.
Table 3.

Some Antigens Responsible for Work-related Asthma


    High MW antigens

    Occupation animal danders animal handlers insect scales entomologists, lab workers egg white proteins egg producers grain dusts farmers, grain store workers wood dusts saw mill workers, carpenters latex health care workers.

    Low MW antigens

    Diisocyantes workers in printing and painting industry anhydrides workers in plastics and drug industries metallic salts tool and dye workers antibiotics pharmaceutical workers.

    Low molecular weight diisocyanates
    are the leading causes of occupational asthma; they are used in many different manufacturing processes and their fumes can sensitize the worker. Occupational asthma can also occur in clean environments, such as in the pharmaceutical industry, where workers may develop sensitization after repeated exposed to low molecular weight antibiotics; an example is latex allergy.

How does asthma arise from latex allergy?

Latex allergy is an example of occupational asthma in a clean environment. Latex allergy in health care workers appears to be increasing in incidence. Latex, or natural rubber, is found in many medical products, particularly gloves. Latex allergy is also seen in patients repeatedly exposed to health care workers' gloves and other latex-containing products. Allergic reactions range from contact hives (skin reaction only) to asthma and in some extreme cases, shock (anaphylaxis). For this reason many hospitals and dental offices have switched to non-latex gloves and other products. (Note that latex is not just confined to gloves, but is a component of numerous other hospital products, including intravenous lines and ventilation bags.) Factors predisposing to latex allergy include a history of other allergies (such as hives or hay fever) and frequent exposure to latex products. Sensitization to latex doesn't happen after a single exposure; instead, the worker becomes sensitized to the latex after repeated exposures, over time. Antibodies gradually build up until there is sufficient amount to produce an antigen (latex)-antibody reaction that produces bronchial inflammation and symptoms. Asthma from latex allergy is thought to arise from repeated inhalation of airborne latex particles that adhere to the cornstarch used to powder gloves. (Cornstarch is placed in gloves to make them easy to slip on and off.)
What is RADS?

RADS, or reactive airways dysfunction syndrome, was first described in the 1985, is now a well-recognized form of occupational asthma. It is non-immunologic, i.e., unrelated to allergy. The exposure is obvious and the symptoms are usually immediate, although they may gradually worsen over the first 24 hours (see Table 4). The inhaled irritant (e.g., fumes from a chemical spill), causes direct irritation of the lining of the bronchial tubes, leading to asthma symptoms. Symptoms can persist long after exposure, and indeed become chronic and disabling.
Table 4.

Reactive Airways Dysfunction Syndrome (RADS)

    Exposure to a high concentration of irritant gas, smoke, fume, or vapor
    Immediate onset of symptoms after single exposure to the irritant, although symptoms may not peak for several hours
    Documented absence of preceding respiratory complaints
    Symptoms (cough, wheeze and/or dyspnea) persist at least 3 months
    Presence of airflow obstruction on pulmonary function testing
    Presence of non-specific bronchial hyper-responsiveness
    Other pulmonary diseases ruled out

How do I know if I have work-related asthma?

Sometimes it's obvious, sometimes very difficult to know. While there are a variety of sophisticated tests (including blood and breathing tests) to help physicians diagnose this condition, perhaps the most important is the medical history. Medical history includes information about your medical condition before the job began and the specific relationship of your symptoms to job activities. For example, an obvious case of occupational asthma would be a 30-year-old woman who:

a) never smoked;
b) never had asthma or respiratory symptoms before starting a new job;
c) after working on a new job for months to years, develops wheezing, cough and shortness of breath;
d) notes that her symptoms get better away from work (weekends, or vacation), and flare again back at work;
e) works with a specific chemical that is known to cause occupational asthma (e.g., toluene diisocyante);
fe) is diagnosed with asthma by breathing tests.
A much more difficult case would be a 35-year-old man who:

a) currently smokes, and has smoked a pack a day for 15 years;
b) has a history of episodes of bronchitis before taking a new job in a factory at age 34;
c) develops a respiratory infection with fever, and then notes trouble breathing;
d) gets more short of breath when he returns to work after recovering from the infection.
This patient may in fact have smoking-related chronic obstructive disease exacerbated by infection, and not work-related asthma. Only by testing and further history could a physician make a reasonable determination.
I might have work-related asthma B What should I do?

There is one cardinal rule that every worker must remember: Your health comes first. If asthma occurs on the job, and the job doesn't change, the asthma won't get better. The worker must remove himself or herself from the environment. If this is you, I recommend seeing an asthma specialist as soon as possible. Be prepared to give a detailed history of your symptoms and their relationship to the job. Ideally, this information should be written down and handed to the physician. If there is a strong suspicion based on your history, your doctor can write a note asking for a position change within the company (if possible), or that you stay off work while tests are performed. Again, the diagnosis may not be obvious, and it may take time to make a reasonable assessment.
Can I get worker's compensation for work-related asthma?

Every state runs a worker's compensation agency, and work-related asthma is certainly compensable. The worker will have to satisfy some stringent medical criteria. Usually, an exam will be ordered with a state physician (i.e., someone other than your treating physician). More often than not, the employer will dispute the diagnosis, and may ask for yet another exam with a physician they designate. Conflicting reports are common, making it difficult for a workers' compensation agency to decide on a case's merits. In truth, these agencies were originally set up to compensate injured workers, and this meant broken limbs and other external injuries. It is much more difficult to adjudicate a medical diagnosis like asthma: a) where the cause is often not obvious; b) in which symptoms can be extremely variable, and c) that is also very common in the general population. Given the potential for disagreement, it is not surprising that the decision of the compensation agency is often appealed. If you think you have work-related asthma, by all means get it checked out, but don't expect a speedy resolution. And remember: your health comes first.
Does cigarette smoking predispose to occupational asthma? If I smoke will it be more difficult to prove I have occupational asthma? Will my symptoms likely improve if I quit smoking?

Yes. Yes. Yes. No point in belaboring the obvious.

I have asthma and am taking several medications that control my condition. Should I still avoid a dusty environment?

By all means, yes. The fact that you need asthma medications to control your condition is warning flag; any dusty environment could trigger your symptoms. Note that the offending work environment could be outdoors, e.g., work around diesel truck fumes or dust in an outdoor saw mill. Or, it could be indoors in a non-factory setting, such as a smoke-filled bar. Evaluate your potential job environment carefully if you have asthma.
Is treatment of occupational asthma different from regular asthma?

Treatment of work-related asthma is no different from asthma unrelated to the job, with one important exception: advice about continued working. If a worker has developed an allergic reaction to something in the environment (i.e., is sensitized to it), he or she must leave that environment. The quicker they remove themselves, the better the outcome; studies have shown that continued exposure to the sensitizing agent is associated with further deterioration of lung function. Masks and other devices to minimize the exposure are of no help, and should not be relied on. Even tiny amounts of allergen can trigger a reaction if the worker is sensitized to it. On the other hand, if the asthma was due to a one-time irritant exposure, and the irritant is removed completely, than there should be no contraindication to continued working in that environment. Sometimes, though, other pollutants in the environment may bother the worker more than before, even though the specific agent causing the asthma is removed. Although stopping exposure generally results in clinical improvement, this is not invariable, particularly if the worker is a smoker or has co-existing sinusitis (which can also trigger asthma exacerbations). Even without these other conditions, the patient may continue to manifest asthma symptoms and require medication for months or years after leaving the job.

I hear what you say, and I have asthma symptoms at work, but there is no way I can quit my job. What can I take for it?

If that is your situation, then you must work with a physician to find the best strategy. Generally, this is two-fold. First, some type of airway protection (masks, changes in ventilation at the work site, etc.) that your doctor may be able to recommend to your employer. Second, there are numerous asthma medications on the market, and finding the proper regimen is often a matter of trial and error. If you continually function on two (out of 6) cylinders day in and day out, you could end up a respiratory cripple. With attention to airway protection, and proper medication, your physician may be able to get you up to 4 or 5 cylinders, and still keep you on the job.